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Conclusions: The GentleWave® System showed a significantly greater cleaning capacity and reduction in residual debris within the mesiobuccal and mesiolingual canals of mandibular molars and the mesiobuccal canals of maxillary molars than those cleaned with standard methods.

Conclusions: The GentleWave^® System creates negative pressure at the apical foramen during root canal cleaning, irrespective of the size of canal instrumentation. Positive apical pressures were measured for syringe irrigation.

Conclusions: When patients were treated with the GentleWave® System, the cumulative success rate of healing was 97.4% at six months.

Conclusions: Recent advances in root canal disinfection using new technology and on the basis of recent studies may improve the ability to disinfect the root canal system.

Conclusions: At 3- and 6-month recalls post GentleWave® Procedure, the tooth was asymptomatic, with a marked reduction in the size of the periradicular lesion around the mesial and distal roots.

Conclusions: Treatment of sizable periapical lesions with the GentleWave® System resulted in a cumulative healing success rate of 97.7% at 12 months.