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Conclusions: The GentleWave^® System demonstrated at least four times deeper cleaning in the apical region than currently employed ultrasonic systems.

Conclusions: Recent advances in root canal disinfection using new technology and on the basis of recent studies may improve the ability to disinfect the root canal system.

Conclusions: The GentleWave® System showed a significantly greater cleaning capacity and reduction in residual debris within the mesiobuccal and mesiolingual canals of mandibular molars and the mesiobuccal canals of maxillary molars than those cleaned with standard methods.

Conclusions: When patients were treated with the GentleWave® System, the cumulative success rate of healing was 97.4% at six months.

Conclusions: NaOCl followed by final EDTA irrigation performed either by syringe needle or the GentleWave^® System caused minimal dentin erosion. 

Conclusions: The GentleWave® System was compared with a negative pressure system and resulted in no apical extrusion.