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Conclusions: The GentleWave^® System demonstrated at least four times deeper cleaning in the apical region than currently employed ultrasonic systems.

Conclusions: NaOCl followed by final EDTA irrigation performed either by syringe needle or the GentleWave^® System caused minimal dentin erosion. 

Conclusions: When patients were treated with the GentleWave® System, the cumulative success rate of healing was 97.3% at twelve months.

Conclusions: Recent advances in root canal disinfection using new technology and on the basis of recent studies may improve the ability to disinfect the root canal system.

Conclusions: In this study, the novel GentleWave® System achieved seven times faster tissue dissolution rates when using 3% NaOCI as compared to the other systems examined, including passive and active ultrasonic systems.

Conclusions: The GentleWave® System showed a significantly greater cleaning capacity and reduction in residual debris within the mesiobuccal and mesiolingual canals of mandibular molars and the mesiobuccal canals of maxillary molars than those cleaned with standard methods.